Melatonin: Pharmacology, Functions and Therapeutic Benefits

  title={Melatonin: Pharmacology, Functions and Therapeutic Benefits},
  author={Sylvie Tordjman and Sylvie Chokron and Richard Delorme and Anna{\"e}lle Charrier and Eric Bellissant and Nemat Jaafari and Claire Fougerou},
  booktitle={Current neuropharmacology},
BACKGROUND Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24… CONTINUE READING
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