Melatonin: Characteristics, Concerns, and Prospects

  title={Melatonin: Characteristics, Concerns, and Prospects},
  author={Jos{\'e}phine Arendt},
  journal={Journal of Biological Rhythms},
  pages={291 - 303}
  • J. Arendt
  • Published 1 August 2005
  • Biology, Medicine
  • Journal of Biological Rhythms
Melatonin is of great importance to the investigation of human biological rhythms. Its rhythm in plasma or saliva provides the best available measure of the timing of the internal circadian clock. Its major metabolite 6-sulphatoxymelatonin is robust and easily measured in urine. It thus enables long-term monitoring of human rhythms in real-life situations where rhythms may be disturbed, and in clinical situations where invasive procedures are difficult. Melatonin is not only a “hand of the… 

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