Melatonin, sleep disturbance and cancer risk.

@article{Blask2009MelatoninSD,
  title={Melatonin, sleep disturbance and cancer risk.},
  author={David E. Blask},
  journal={Sleep medicine reviews},
  year={2009},
  volume={13 4},
  pages={
          257-64
        }
}
  • D. Blask
  • Published 1 August 2009
  • Biology, Medicine
  • Sleep medicine reviews
The pineal hormone melatonin is involved in the circadian regulation and facilitation of sleep, the inhibition of cancer development and growth, and the enhancement of immune function. Individuals, such as night shift workers, who are exposed to light at night on a regular basis experience biological rhythm (i.e., circadian) disruption including circadian phase shifts, nocturnal melatonin suppression, and sleep disturbances. Additionally, these individuals are not only immune suppressed, but… 
Cancer and Sleep: Cancer is a Circadian Rhythm Disorder
TLDR
Evidence mounts that melatonin, with its many anticancer properties, may play an important role in the pathophysiology of cancer.
The Role of Melatonin in Cancer Development
TLDR
Experimental evidence depicting the role of melatonin in the prevention of cancer development is focused on and studies have shown that melatonin significantly suppresses cell proliferation and induces apoptosis.
Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review
TLDR
This work reviews and synthesizes the literature, including evidence for bidirectional interactions between sleep and circadian systems, and potential mechanistic pathways by which interrelatedSleep and circadian disruption may contribute to the etiology of breast cancer.
Circadian Disruption, Sleep Loss, and Prostate Cancer Risk: A Systematic Review of Epidemiologic Studies
TLDR
This review systematically examines available data evaluating the effects of light at night, sleep patterns, and night shift work on prostate cancer risk.
Effects of sleep and circadian rhythm on the human immune system
TLDR
The circadian system and sleep jointly evoke a unique endocrine constellation that is extremely effective in inducing changes in leukocyte traffic and a shift toward proinflammatory type 1‐cytokines during the nocturnal period of sleep, that is, an action with strong clinical implications.
Mechanisms by which circadian rhythm disruption may lead to cancer
TLDR
The correlation of circadian rhythm disruption and cancer in terms of molecular mechanisms affecting circadian gene expression and melatonin secretion is explored.
Shift work: coping with the biological clock.
TLDR
Exposure to and/or avoidance of bright light at specific times of the 'biological night' is the most important factor in manipulating the circadian system.
Night Shifts and Melatonin: Relevance to Age and Breast Cancer
TLDR
Dysfunction of endogenous clocks, melatonin receptor polymorphisms, and age-associated decline of melatonin synthesis are already increased risks of breast cancer, epidemiological studies displayed.
A review on melatonin action as therapeutic agent in cancer
TLDR
Melatonin is considered as a critical hormone that controls and regulates many functions in the authors' body and its most absolute biological role is to convey information to the body about day length for a variety of physiologic functions.
Evaluation and Management of Sleep and Circadian Rhythm Disturbance in Cancer
TLDR
Recognition, evaluation, and treatment of sleep and circadian rhythm disturbance in cancer may lead to improved symptom management, quality of life, and outcomes.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Melatonin, Sleep, and Shift Work Adaptation
TLDR
This ratio may help identify workers at increased risk for accidents or injuries and alter melatonin, disrupted sleep, and elevated symptom prevalence among workers on permanent day, swing, and night shifts.
Melatonin and Human Rhythms
  • J. Arendt
  • Biology, Medicine
    Chronobiology international
  • 2006
TLDR
The future holds much promise for melatonin as a research tool and as a therapy for various conditions as well as the general properties of the human circadian system in health and disease.
Putting cancer to sleep at night
TLDR
Light during darkness suppresses nocturnal melatonin production and stimulates the LA metabolism and growth of rat hepatoma and human breast cancer xenografts and dietary melatonin supplementation working in concert with the endogenous melatonin signal has the potential to be a new preventive/therapeutic strategy to optimize the host/cancer balance.
Meeting Report: The Role of Environmental Lighting and Circadian Disruption in Cancer and Other Diseases
TLDR
A workshop of a diverse group of scientists is convened to consider how best to conduct research on possible connections between lighting and health and how prevention and treatment could be improved by application of this knowledge.
Urinary melatonin levels and breast cancer risk.
TLDR
Preliminary data support the hypothesis that higher melatonin levels, as measured in first morning urine, are associated with a lower risk of breast cancer.
A longer biological night in long sleepers than in short sleepers.
TLDR
It is concluded that the circadian pacemaker programs a longer biological night in long sleepers than in short sleepers, and it is proposed that individual differences in the circadianpacemaker's program may contribute to the variability of sleep duration in the general population.
Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia.
TLDR
The temporal isolation data account quantitatively for the timing of the afternoon siesta and suggest that malfunctions of the phasing of the circadian pacemaker may underlie the insomnia associated with sleep-scheduling disorders.
Profile of 24-h Light Exposure and Circadian Phase of Melatonin Secretion in Night Workers
TLDR
Light exposure was measured in 30 permanent night nurses to determine if specific light/dark profiles could be associated with a better circadian adaptation, and the timing of the main sleep episode was associated with the time of light exposure.
Night shift work, light at night, and risk of breast cancer.
TLDR
Evidence is provided that indicators of exposure to light at night may be associated with the risk of developing breast cancer.
Evidence for a biological dawn and dusk in the human circadian timing system
TLDR
A model of the human circadian timing system in which two states, one diurnal and one nocturnal, alternate with one another is suggested, and in which transitions between the states are switch‐like and are separately entrained to dawn and dusk is suggested.
...
1
2
3
4
5
...