Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis

@article{Poeggeler1993MelatoninHR,
  title={Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis},
  author={Burkhard Poeggeler and Russel Joseph Reiter and Dun-Xian Tan and Lidun Chen and Lucien C. Manchester},
  journal={Journal of Pineal Research},
  year={1993},
  volume={14}
}
Abstract: Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on‐site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non‐enzymatic antioxidative defense against the devastating actions of the extremely reactive hydroxyl radical. Melatonin and structurally related tryptophan metabolites are evolutionary conservative molecules… 
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480 Citations

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