Melatonin, endocrine pancreas and diabetes.

@article{Peschke2007MelatoninEP,
  title={Melatonin, endocrine pancreas and diabetes.},
  author={Elmar Peschke},
  journal={Journal of pineal research},
  year={2007},
  volume={44 1},
  pages={
          26-40
        }
}
Melatonin influences insulin secretion both in vivo and in vitro. (i) The effects are MT(1)-and MT(2)-receptor-mediated. (ii) They are specific, high-affinity, pertussis-toxin-sensitive, G(i)-protein-coupled, leading to inhibition of the cAMP-pathway and decrease of insulin release. [Correction added after online publication 4 December 2007: in the preceding sentence, 'increase of insulin release' was changed to 'decrease of insulin release'.] Furthermore, melatonin inhibits the cGMP-pathway… CONTINUE READING
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