Melatonin, circadian rhythms, and the clock genes in bipolar disorder

  title={Melatonin, circadian rhythms, and the clock genes in bipolar disorder},
  author={S. Dallaspezia and F. Benedetti},
  journal={Current Psychiatry Reports},
  • S. Dallaspezia, F. Benedetti
  • Published 2009
  • Medicine, Psychology
  • Current Psychiatry Reports
  • Sleep disturbances and dysregulation of circadian rhythms are core elements of bipolar disorder that might be involved in its pathogenesis. It has been proposed that patients with bipolar disorder have an abnormally shifted or arrhythmic circadian system and that the disturbance of circadian rhythms may be caused by an alteration in the circadian clock machinery. Chronotherapeutic strategies based on controlled exposures to environmental stimuli that act on biological rhythms have shown good… CONTINUE READING

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