Melasma: systematic review of the systemic treatments

  title={Melasma: systematic review of the systemic treatments},
  author={Linghong Linda Zhou and Akerke T Baibergenova},
  journal={International Journal of Dermatology},
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light‐based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the… 

Systemic therapy for melasma: Exploring newer options − A comprehensive review

The efficacy, safety and tolerability of different systemic anti-melasma agents are reviewed to achieve quicker, better and long-lasting results.

Melasma treatment: a systematic review

Treatment choice should be made after Wood’s lamp examination, as well as dermatoscopic evaluation, in order to select the best treatment option, targeted at each melasma subtype, when compared to single terapies.

Photodynamic Cosmetic Therapy on Melasma Management - Melan Reduxx Program

It is demonstrated that the management of melasma proposed in the melan reduxx program is possible by associating different treatment strategies as: professional procedures on clinical using low level light professional therapy with laser and LEDs, in different visible wavelengths in the presence of chemical and photoactived peels (professional cosmetics products) as well as home care procedures using topical and oral cosmetics products.

How I manage resistant melasma?

The present article focuses on the management of complicated cases of melasma which are refractory to the treatment of over-the-counter medications containing topical steroids or indigenous medications.

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study

Addition of tranexamic acid injections to conventional hydroquinone therapy can increase the efficacy of topical treatment in patients with melasma.

A Dermoscopic Evaluation of Melasma Treated with Tranexamic Acid

The intradermal usage of TA can actually decrease improved the melasma and the dermoscope could be considered as a useful objective score for melasma.

Nutrological control and treatment of melasma in the COVID-19 pandemic: a concise systematic review

A concise systematic review on the occurrence, worsening, and nutrological treatment of melasma in the COVID-19 pandemic found that lycopene is one of the most effective oxygen neutralizers among tomato-derived carotenoids and hydroquinone is a compound that has been used for the treatment of hyperpigmentation by tyrosinase inhibition mechanism.

Comparative study of efficacy of intradermal tranexamic acid versus topical tranexamic acid versus triple combination in melasma

TA can be used as potentially a new, effective, safe, and promising therapeutic agent in melasma on the basis of these results.

A split face comparative study between intradermal tranexamic acid and Erbium-YAG laser in treatment of melasma

A promising results were obtained by both intradermal TA and Erbium:YAG laser; however, the TA yields a higher patient satisfaction because of its high efficiency and low cost.

Self‐applied topical interventions for melasma: a systematic review and meta‐analysis of data from randomized, investigator‐blinded clinical trials *

Melasma is a common dermatological condition that may affect the patient’s wellbeing and quality of life and a broad range of treatment options is available.



Treatment of Melasma With Oral Administration of Tranexamic Acid

Oral administration of tranexamic acid (TA) is an effective and safe therapy for the treatment of melasma and is graded into four levels: excellent, good, fair, and poor.

Polypodium leucotomos as an Adjunct Treatment of Pigmentary Disorders.

In addition to preventing many harmful effects associated with sunlight exposure, orally administered Polypodium leucotomos also appears to provide adjunctive benefits in treating vitiligo, melasma, and may have the potential to help with postinflammatory hyperpigmentation.

Melasma: a comprehensive update: part II.

Role of oral tranexamic acid in melasma patients treated with IPL and low fluence QS Nd:YAG laser

Oral TNA may improve clinical efficacy in light- or laser-based melasma treatment especially during the period of relative high sun exposure without serious adverse effects.

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for Preventing Postinflammatory Hyperpigmentation After Q‐Switched Ruby Laser

  • H. KatoJ. Araki K. Yoshimura
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2011
Although oral TA has been reported to have depigmentation effects, it may not be effective for preventing PIH after QSRL, and an optimal protocol may be needed to induce the efficacy of this treatment to achieve the PIH‐preventing effect of oral TA.

Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial

Addition of oral tranexamic acid to fluocinolone-based triple combination cream results in a faster and sustained improvement in the treatment of melasma.

Safety and Efficacy of Oral Polypodium leucotomos Extract in Healthy Adult Subjects.

Polypodium leucotomos extract 240mg taken twice daily for 60 days was a safe and effective means for reducing the damaging effects of ultraviolet radiation.

Oral Tranexamic Acid Enhances the Efficacy of Low‐Fluence 1064‐Nm Quality‐Switched Neodymium‐Doped Yttrium Aluminum Garnet Laser Treatment for Melasma in Koreans: A Randomized, Prospective Trial

Oral TA may prove a safe and efficient treatment option for melasma in combination with low‐fluence QSNY laser therapy, and a greater number of patients scored as grade 3 and more in the combination group.