Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study.

@article{Snchez1981MelasmaAC,
  title={Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study.},
  author={N. S{\'a}nchez and M. Pathak and S. Sato and T. Fitzpatrick and J. S{\'a}nchez and M. Mihm},
  journal={Journal of the American Academy of Dermatology},
  year={1981},
  volume={4 6},
  pages={
          698-710
        }
}
Melasma is an acquired brown hypermelanosis of the face. Although it is thought that melasma is associated with multiple etiologic factors (pregnancy, gastric, racial, and endocrine), one of the primary causes of its exacerbation appears to be exposure to sunlight. Three patterns of melasma are recognized clinically: (1) a centrofacial pattern, (2) a malar pattern, and (3) a mandibular pattern. Examination of patients with Wood's light (320--400 nm) is useful in classifying the specific type of… Expand

Paper Mentions

Interventional Clinical Trial
1. To detect the efficacy and safety of combined TCA and MDA in treating melasma. 2. To compare the efficacy and safety of using different TCA concentrations (15% & 20… Expand
ConditionsMelasma
InterventionDrug
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TLDR
The clinicoepidemiological pattern and the precipitating or provocation factors in melasma are studied, finding an association with endocrinal diseases and observing that 5 of them had hypothyroidism. Expand
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TLDR
Initial clearance of pigmentation with clobetasol propionate was encouraging though the success was shortlived, and the patients were advised to use a sun screen and Histopathologically, the pigmentation is either epidermal or dermal. Expand
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TLDR
Intense pulsed light stands out as an effective tool in the treatment and healing of a high percentage of hypermelanosis and melasma, with a very low risk of complications and an excellent satisfaction rate among patients. Expand
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555 Melasma, a commonly acquired hypermelanosis, presents as symmetrical irregular to dark-brown macules on sun-exposed areas such as the face, particularly over the forehead and malar areas, andExpand
The treatment of melasma: a review of clinical trials.
TLDR
Combination therapies such as hydroquinone, tretinoin, and corticosteroids have been used in the treatment of melasma, and are thought to increase efficacy as compared with monotherapy, but their efficacy, safety, or trial design indicates that the interventions would need further study before they could be recommended. Expand
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TLDR
Melasma is an acquired hyperpigmentary disorder commonly seen in Orientals and multiple causative factors have been implicated in the aetiology; sunlight appears to be the most important in causing and aggravating the condition in susceptible individuals. Expand
Diagnosis of Melasma in Brown Skin: Wood’s Lamp, Dermoscopy, and Confocal Microscopy
TLDR
The diagnosis of melasma is usually made clinically and is rather straightforward due to its characteristic appearance, but the use of additional tools such as Wood’s lamp, dermoscopy, and reflectance confocal microscopy (RCM) may help to identify the depth of the pigment. Expand
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Reflectance Confocal Microscopy emerges as a reliable adjuvant technique for the classification, diagnosis and overall management of melasma. Expand
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