Melanotransferrin: search for a function.

  title={Melanotransferrin: search for a function.},
  author={Yohan Suryo Rahmanto and Sumeet Bal and Kim H Loh and Yu Yu and Des. R. Richardson},
  journal={Biochimica et biophysica acta},
  volume={1820 3},
BACKGROUND Melanotransferrin was discovered in the 1980s as one of the first melanoma tumour antigens. The molecule is a transferrin homologue that is found predominantly bound to the cell membrane by a glycosyl-phosphatidylinositol anchor. MTf was described as an oncofoetal antigen expressed in only small quantities in normal tissues, but in much larger amounts in neoplastic cells. Several diseases are associated with expression of melanotransferrin, including melanoma and Alzheimer's disease… CONTINUE READING


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