Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.

@article{Carrasco2006MelanoticNT,
  title={Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.},
  author={Carmen M A Carrasco and David Rojas-Salazar and Renato Chiorino and Juan C Venega and Nelson G Wohllk},
  journal={Neurosurgery},
  year={2006},
  volume={59 6},
  pages={E1334-5; discussion E1335}
}
OBJECTIVE Melanotic schwannoma is a rare neoplasm, classifiable as a peripheral nerve sheath tumor, and differentiated from a typical schwannoma by heavy pigmentation. Psammoma bodies can be visualized in more than 50% of melanotic schwannomas. Half of patients with such "psammomatous melanotic schwannomas" have Carney complex, a dominantly transmitted autosomal disorder. Most recently, the tumor suppressor gene, PRKAR1A, coding for the Type 1alpha regulatory subunit of protein kinase A was… CONTINUE READING
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