Melanosomal damage in normal human melanocytes induced by UVB and metal uptake--a basis for the pro-oxidant state of melanoma.

@article{Gidanian2008MelanosomalDI,
  title={Melanosomal damage in normal human melanocytes induced by UVB and metal uptake--a basis for the pro-oxidant state of melanoma.},
  author={Shirley Gidanian and Mallory Mentelle and Frank L. Meyskens and Patrick J Farmer},
  journal={Photochemistry and photobiology},
  year={2008},
  volume={84 3},
  pages={556-64}
}
Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes within melanocytes, the function of which is to protect skin against harmful effects of UV radiation. Melanosomes within melanoma cells are characteristically abnormal, with fragmented melanin and disrupted membranes. We hypothesize that the disruption of melanosomal melanin might be an early event in the etiology and progression of melanoma, leading to increased oxidative stress and mutation. In this report… CONTINUE READING
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