Melanosomal antigenic expression on the cell surface and intracellular subunits within melanogenic compartments of pigment cells: analysis by antimelanosome-associated monoclonal antibody.

@article{Hayashibe1986MelanosomalAE,
  title={Melanosomal antigenic expression on the cell surface and intracellular subunits within melanogenic compartments of pigment cells: analysis by antimelanosome-associated monoclonal antibody.},
  author={Kazuhito Hayashibe and Yutaka Mishima and Masamitsu Ichihashi and Mari Kawai},
  journal={The Journal of investigative dermatology},
  year={1986},
  volume={87 1},
  pages={89-94}
}
Antimelanosome-associated monoclonal antibody has recognized the common antigenic determinant of melanosomes and cell surface of pigment cells, and it is suggested that melanosomes play a significant role as an antigen in progressive depigmentary disorders, in which melanocytes are selectively altered and disappear presumably by auto-antibodies in vivo. Mouse myeloma cells were fused with spleen cells from BALB/c mice immunized with a melanosomal fraction separated from human melanotic melanoma… CONTINUE READING

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