Melanopsin retinal ganglion cells and circadian dysfunction in Alzheimer´s disease

@inproceedings{Morgia2013MelanopsinRG,
  title={Melanopsin retinal ganglion cells and circadian dysfunction in Alzheimer´s disease},
  author={Chiara La Morgia and Roberto Gallassi and Luisa Sambati and Federica Provini and Fn Ross-Cisneros and Billy X. Pan and Piero Barboni and Pietro Avanzini and Gaetano Cantalupo and Jens Hannibal and Alfredo Arrigo Sadun and V Carelli},
  year={2013}
}
Purpose To evaluate optic nerve and in particular melanopsin retinal ganglion cells (mRGCs) in relation to rest-activity rhythm in Alzheimer disease (AD). Methods Retinal nerve fiber layer (RNFL) thickness measurements by optical coherence tomography were performed in 21 AD and 74 age-matched controls. Actigraphic monitoring was performed in 16 AD patients and 10 age-matched controls. Non-parametric methods were applied to assess interdaily stability (IS), intradaily variability (IV) and… CONTINUE READING