Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice

@article{Hattar2003MelanopsinAR,
  title={Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice},
  author={S. Hattar and R. Lucas and N. Mrosovsky and S. Thompson and R. Douglas and M. Hankins and J. Lem and M. Biel and F. Hofmann and R. Foster and K. Yau},
  journal={Nature},
  year={2003},
  volume={424},
  pages={75-81}
}
In the mammalian retina, besides the conventional rod–cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment. On ablation of the melanopsin gene, retinal ganglion cells that normally express melanopsin are no longer intrinsically photosensitive. Furthermore, pupil reflex, light-induced phase delays of the circadian clock and period lengthening of the circadian… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
TLDR
It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other non–image-forming visual functions. Expand
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
TLDR
It is reported that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. Expand
Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice.
TLDR
Data indicate that classical opsins and cryptochromes serve functionally redundant roles in the transduction of light information to behavioral modulation and suggest a pleomorphic role for cryptochrome in both photoreception and central clock mechanism. Expand
Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics
TLDR
The data suggest that both cone classes of the mouse may mediate the photic regulation of circadian rhythms, and if this is the case, circadian sensitivity can be maintained by very few degenerate cones. Expand
Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
TLDR
It is shown that retinal ganglion cells innervating the SCN are intrinsically photosensitive, and depolarized in response to light even when all synaptic input from rods and cones was blocked. Expand
Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+) mice
TLDR
The spectral sensitivity of CBA/J-rd/rd mice clearly fitted to the Dartnall nomogram for a retinal1-based pigment with amaximum at 480 nm, while the best fitted nomogram had a maximum at 500 nm in CBA-N- +/+ mice. Expand
The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract
TLDR
Cloned rat melanopsin photopigment cDNA is cloned and in situ hybridization histochemistry combined with immunohistochemistry and colocalization studies reveal that melanops in was found exclusively in the PACAP-containing retinal ganglion cells located at the surface of somata and dendrites. Expand
Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit
TLDR
Most if not all rods use a single transducin type in phototransduction, as expected for a cone, but had a rod-like spectral sensitivity and flash response kinetics that were slow, even for rods. Expand
Characterization of an ocular photopigment capable of driving pupillary constriction in mice
TLDR
This work demonstrates that transgenic mice lacking both rod and cone photoreceptors (rd/rd cl) retain a pupillary light reflex (PLR) that does not rely on local iris photoreCEPTors, and represents the first functional characterization of a non-rod, non-cone photoreceptive system in the mammalian CNS. Expand
Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting
TLDR
These mice display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals. Expand
...
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2
3
4
5
...