Melanopsin Mediates Retrograde Visual Signaling in the Retina

  title={Melanopsin Mediates Retrograde Visual Signaling in the Retina},
  author={Dao-Qi Zhang and Michael A. Belenky and Patricia J Sollars and Gary E. Pickard and Douglas G McMahon},
  booktitle={PloS one},
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde… CONTINUE READING
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