Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice
@article{Panda2003MelanopsinIR, title={Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice}, author={Satchidananda Panda and Ignacio Provencio and Daniel C. Tu and Susana Salgado Pires and Mark D. Rollag and Ana Maria Castrucci and Mathew T. Pletcher and Trey K. Sato and Tim Wiltshire and Mary Andahazy and Steve A. Kay and Russell N. Van Gelder and John B. Hogenesch}, journal={Science}, year={2003}, volume={301}, pages={525 - 527} }
Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin, a photopigment that confers this photosensitivity. Mice lacking melanopsin still retain nonvisual photoreception, suggesting that rods and cones could operate in this capacity. We observed that mice with both outer-retinal degeneration and a deficiency in melanopsin exhibited complete loss of…
686 Citations
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