Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision

@article{Ecker2010MelanopsinExpressingRG,
  title={Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision},
  author={Jennifer L. Ecker and Olivia Dumitrescu and Kwoon Y Wong and Nazia Alam and Shih-Kuo Chen and Tara A Legates and Jordan M Renna and Glen T. Prusky and David M. Berson and Samer S Hattar},
  journal={Neuron},
  year={2010},
  volume={67},
  pages={49-60}
}
Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction. We now report that ipRGCs are more abundant and diverse than previously appreciated, project more widely within the brain, and can support spatial visual perception. A Cre-based melanopsin reporter mouse line revealed at least five subtypes of ipRGCs with distinct morphological and physiological characteristics… CONTINUE READING
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