Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.

@article{Provance2002MelanophilinTP,
  title={Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.},
  author={David William Provance and Ted L. James and John A. Mercer},
  journal={Traffic},
  year={2002},
  volume={3 2},
  pages={124-32}
}
The formation of complex subcellular organelles requires the coordinated targeting of multiple components. Melanosome biogenesis in mouse melanocytes is an excellent model system for studying the coordinated function of multiple gene products in intracellular trafficking. To begin to order events in melanosome biogenesis and distribution, we employed the classical coat-color mutants ashen, dilute, and leaden, which affect melanosome distribution, but not melanin synthesis. The loci have been… CONTINUE READING

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