Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression

@article{Ferguson2015MelanomaSA,
  title={Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression},
  author={BenjaminD. Ferguson and Rashmi Ram and Herlina Y. Handoko and Partha Mukhopadhyay and Hans Konrad Muller and H. Peter Soyer and Grant Morahan and Graeme J. Walker},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={2879-2886}
}
Susceptibility to most common cancers is likely to involve interaction between multiple low risk genetic variants. Although there has been great progress in identifying such variants, their effect on phenotype and the mechanisms by which they contribute to disease remain largely unknown. We have developed a mouse melanoma model harboring two mutant… CONTINUE READING