Melanoma mutagenesis and aberrant cell signaling.

  title={Melanoma mutagenesis and aberrant cell signaling.},
  author={Danielle M. Bello and Charlotte Eielson Ariyan and Richard D. Carvajal},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  volume={20 4},
BACKGROUND Malignant melanoma is the most fatal type of skin cancer. Traditional melanoma classification has been based on histological subtype or anatomical location. However, recent evidence suggests that melanoma comprises a group of diseases characterized by distinct molecular mutations. These mutations affect disease behavior but provide unique opportunities for targeted therapy. METHODS In this review, several signaling pathways in melanoma are described as well as how mutations of BRAF… CONTINUE READING