Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.

@article{Russ2011MelanomainducedSO,
  title={Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.},
  author={Andrew J. Russ and Kyle Y. Xu and Lucy Wentworth and Sheeba Alam and Justin V. Meyers and Michael D. Macklin and Alexander L. Rakhmilevich and Victoria P Rajamanickam and Marulasiddappa Suresh and Clifford S. Cho},
  journal={Cellular immunology},
  year={2011},
  volume={271 1},
  pages={104-9}
}
We have observed that in vivo interaction between melanoma and resting T cells promotes suppression of antigen-driven proliferative T cell expansion. We hypothesized that this suppression would affect tumor antigen-specific T cell populations more potently than tumor-unrelated T cell populations. A B16F10 cell line was stably transfected to express low levels of the lymphocytic choriomeningitis virus (LCMV) glycoprotein GP33 (B16GP33). Mice bearing B16F10 or B16GP33 tumors were infected with… CONTINUE READING