Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.


We have observed that in vivo interaction between melanoma and resting T cells promotes suppression of antigen-driven proliferative T cell expansion. We hypothesized that this suppression would affect tumor antigen-specific T cell populations more potently than tumor-unrelated T cell populations. A B16F10 cell line was stably transfected to express low… (More)
DOI: 10.1016/j.cellimm.2011.06.011