Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.

@article{Rahmani2010MelanomaDA,
  title={Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.},
  author={Mohamed Rahmani and Mandy Mayo and Rupesh Dash and Upneet K Sokhi and Igor P. Dmitriev and Devanand Sarkar and Paul Dent and David T. Curiel and Paul B Fisher and Steven Grant},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 6},
  pages={1096-104}
}
Melanoma differentiation associated gene-7 (mda-7)/interleukin-24 (IL-24), a member of the IL-10 cytokine gene family, preferentially induces cell death in neoplastic epithelial cells types while sparing their normal counterparts. The effects of mda-7/IL-24 in acute myeloid leukemia (AML) cells have not been extensively characterized. Treatment with recombinant GST-MDA-7/IL-24 potently induced apoptosis in diverse myeloid leukemia cell types including U937, HL60, MV4-11, EOL-1, and MLL/ENL… CONTINUE READING