Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.

@article{Nguyen2011MelanomaCI,
  title={Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.},
  author={Natalie L Nguyen and Arati Sharma and Nhung V Nguyen and Arun Kumar Sharma and Dhimant Desai and Sung Jin Huh and S. T. Amin and Craig Meyers and Gavin P Robertson},
  journal={Cancer prevention research},
  year={2011},
  volume={4 2},
  pages={248-58}
}
Melanoma incidence and mortality rates continue to increase despite the use of sunscreen as well as screening programs for early surgical excision of premalignant lesions. The steady increase in melanoma incidence suggests that additional preventive approaches are needed to augment these existing strategies. One unexplored area involves targeting genes whose deregulation promotes disease development to prevent melanoma. The Akt3 signaling pathway is one key signaling cascade that plays a… CONTINUE READING