Melanoma cells express elevated levels of phosphorylated histone H2AX foci.

@article{Warters2005MelanomaCE,
  title={Melanoma cells express elevated levels of phosphorylated histone H2AX foci.},
  author={Raymond L. Warters and Patrick J Adamson and Christopher D Pond and Sancy A. Leachman},
  journal={The Journal of investigative dermatology},
  year={2005},
  volume={124 4},
  pages={807-17}
}
When human cells sustain a DNA double-strand break (dsb), histone H2AX in chromatin surrounding the DNA break is phosphorylated, marking repair foci. The number of phosphorylated histone H2AX (gammaH2AX) foci approximates the number of dsb present in the cell's nuclear DNA. We observed 0.4 gammaH2AX foci per nucleus in primary human melanocytes. In contrast, in four melanoma cell lines, we detected 7-17 gammaH2AX foci per nucleus, a 17-42 times increase in the basal level of gammaH2AX foci in… CONTINUE READING

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