Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8.

@article{Dong2005MelanomaCE,
  title={Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8.},
  author={Cheng Dong and Margaret J. Slattery and Shile Liang and Hsin-Hsin Peng},
  journal={Molecular & cellular biomechanics : MCB},
  year={2005},
  volume={2 3},
  pages={145-59}
}
Attachment of tumor cells to the endothelium (EC) under flow conditions is critical for the migration of tumor cells out of the vascular system to establish metastases. Innate immune system processes can potentially promote tumor progression through inflammation dependant mechanisms. White blood cells, neutrophils (PMN) in particular, are being studied to better understand how the host immune system affects cancer cell adhesion and subsequent migration and metastasis. Melanoma cell interaction… CONTINUE READING

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