Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

@article{Hammond2013MelanomaassociatedMI,
  title={Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.},
  author={Dean Hammond and Kang Zeng and Antonio Espert and Ricardo Nunes Bastos and Ryan D. Baron and Ulrike Gruneberg and Francis A Barr},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 15},
  pages={3429-40}
}
Mutations in the PPP6C catalytic subunit of protein phosphatase 6 (PP6) are drivers for the development of melanoma. Here, we analyse a panel of melanoma-associated mutations in PPP6C and find that these generally compromise assembly of the PP6 holoenzyme and catalytic activity towards a model substrate. Detailed analysis of one mutant, PPP6C-H114Y, in both primary melanoma and engineered cell lines reveals it is destabilized and undergoes increased proteasome-mediated turnover. Global analysis… CONTINUE READING
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A landscape of driver mutations in melanoma

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