Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A

@article{Hammond2013MelanomaassociatedMI,
  title={Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A},
  author={D. Hammond and K. Zeng and Antonio Espert and R. Bastos and R. D. Baron and U. Gruneberg and F. Barr},
  journal={Journal of Cell Science},
  year={2013},
  volume={126},
  pages={3429 - 3440}
}
  • D. Hammond, K. Zeng, +4 authors F. Barr
  • Published 2013
  • Medicine, Biology
  • Journal of Cell Science
  • Summary Mutations in the PPP6C catalytic subunit of protein phosphatase 6 (PP6) are drivers for the development of melanoma. Here, we analyse a panel of melanoma-associated mutations in PPP6C and find that these generally compromise assembly of the PP6 holoenzyme and catalytic activity towards a model substrate. Detailed analysis of one mutant, PPP6C-H114Y, in both primary melanoma and engineered cell lines reveals it is destabilized and undergoes increased proteasome-mediated turnover. Global… CONTINUE READING
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