Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways

@inproceedings{LaPak2018MelanomaassociatedMW,
  title={Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways},
  author={Kyle M. LaPak and Dennis C. Vroom and Ayush A. Garg and Xiangnan Guan and John L. Hays and Jonathan W Song and Christin E Burd},
  booktitle={Oncotarget},
  year={2018}
}
The overexpression and hyperactivity of p21-activated serine/threonine kinases (PAKs) is known to facilitate tumorigenesis; however, the contribution of cancer-associated PAK mutations to tumor initiation and progression remains unclear. Here, we identify p21-activated serine/threonine kinase 5 (PAK5) as the most frequently altered PAK family member in human melanoma. More than 60% of melanoma-associated PAK5 gene alterations are missense mutations, and distribution of these variants throughout… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 87 REFERENCES

Inhibitors of p21-activated kinases (PAKs).

  • Journal of medicinal chemistry
  • 2015
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.

  • The Journal of biological chemistry
  • 2013
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Methods for cell and particle tracking.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Role of p-21-activated kinases in cancer progression.

  • International review of cell and molecular biology
  • 2014
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…