Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.

@article{Bai2005MelanomaAG,
  title={Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.},
  author={Suxia Bai and Bin He and Elizabeth M. Wilson},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 4},
  pages={1238-57}
}
Gene activation by steroid hormone receptors involves the recruitment of the steroid receptor coactivator (SRC)/p160 coactivator LXXLL motifs to activation function 2 (AF2) in the ligand binding domain. For the androgen receptor (AR), AF2 also serves as the interaction site for the AR NH(2)-terminal FXXLF motif in the androgen-dependent NH(2)-terminal and carboxyl-terminal (N/C) interaction. The relative importance of the AR AF2 site has been unclear, since the AR FXXLF motif interferes with… CONTINUE READING

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