Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom.

  title={Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom.},
  author={Julia A. Newton-Bishop and Yu-Mei Chang and Mark M. Iles and John C. Taylor and Bert Bakker and May K M Chan and Susan Leake and Birute Karpavicius and Sue Haynes and Elaine Fitzgibbon and Faye Elliott and Peter A. Kanetsky and Mark Harland and Jennifer H. Barrett and D Timothy Bishop},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={19 8},
BACKGROUND Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk. METHODS We report nevus phenotype in relation to differing patterns of sun exposure, inherited variation at loci shown in recent genome-wide association studies to be nevus genes, and risk. RESULTS Increased numbers of nevi were associated with… CONTINUE READING


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Melanocytic nevi , nevus genes , and melanoma risk in a large case – control study in the United Kingdom

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