Melanocyte-specific cell mediated immune response in vitiliginous Smyth line chickens.

@article{Wang2003MelanocytespecificCM,
  title={Melanocyte-specific cell mediated immune response in vitiliginous Smyth line chickens.},
  author={Xiuli Wang and G F Erf},
  journal={Journal of autoimmunity},
  year={2003},
  volume={21 2},
  pages={149-60}
}
Smyth line chickens (SL) are an animal model to study human autoimmune vitiligo. Vitiligo in SL chickens is characterized by a post-hatch loss of feather melanocytes (MC) resulting in feather depigmentation. The etiopathology of this disease remains unclear, however, a hypothesis that cell-mediated immunity (CMI) plays an important role in the destruction of melanocytes has been proposed based on previous studies. To support this hypothesis, the delayed wattle response (DWR) to MC lysates was… CONTINUE READING