Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata.

@article{McElwee2001MelanocyteAG,
  title={Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata.},
  author={Kevin John McElwee and Karol Silva and Wesley G. Beamer and Lloyd E. King and John P. Sundberg},
  journal={Experimental dermatology},
  year={2001},
  volume={10 6},
  pages={420-9}
}
Circumstantial evidence has previously suggested gonad derived steroid hormones and melanogenesis related antigens may modify human alopecia areata (AA). AA-like hair loss can be induced in C3H/HeJ mice after skin allografts from spontaneous AA-affected mice. This inducible model was used to evaluate hormones and hair follicle melanocyte presence as disease… CONTINUE READING