Melanocyte‐specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors

@article{Ludwig2004MelanocytespecificEO,
  title={Melanocyte‐specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors},
  author={A. Ludwig and S. Rehberg and M. Wegner},
  journal={FEBS Letters},
  year={2004},
  volume={556}
}
  • A. Ludwig, S. Rehberg, M. Wegner
  • Published 2004
  • Biology, Medicine
  • FEBS Letters
  • Sox10 regulates melanocyte development at least partly through its stimulatory effect on Mitf gene expression. Here, we characterize the gene for dopachrome tautomerase (Dct/Trp2) as the second direct Sox10 target in melanocytes, arguing for the existence of Sox10 functions in melanocytes that are independent of its epistatic relationship to Mitf. Sox10 responsiveness was mediated by multiple binding sites within the proximal Dct/Trp2 promoter which display varying affinities and bind Sox10… CONTINUE READING
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