Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.

@article{Giuliani2014MelanocortinsPA,
  title={Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.},
  author={Daniela Giuliani and Alessandra Bitto and Maria Galantucci and Davide Zaffe and Alessandra Ottani and Natasha Irrera and Laura Neri and Gian Maria Cavallini and Domenica Altavilla and Annibale R. Botticelli and Francesco Squadrito and Salvatore Guarini},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 3},
  pages={537-47}
}
Besides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in occasional studies performed in AD-type dementia patients. Here we investigated the possible neuroprotective role of melanocortins in a chronic neurodegenerative disorder, AD, by using 12-week-old… CONTINUE READING

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References

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Showing 1-10 of 71 references

Immunotherapy against amyloid pathology in Alzheimer's disease.

Journal of the neurological sciences • 2013
View 13 Excerpts
Highly Influenced

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases.

Trends in pharmacological sciences • 2012
View 6 Excerpts
Highly Influenced

Biomarkers in Alzheimer's disease drug development

Alzheimer's & Dementia • 2011
View 10 Excerpts
Highly Influenced

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 5 Excerpts
Highly Influenced

The genetics and neuropathology of Alzheimer’s disease

Acta Neuropathologica • 2012
View 4 Excerpts
Highly Influenced

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