Melanocortins and the brain: from effects via receptors to drug targets.

@article{Adan2000MelanocortinsAT,
  title={Melanocortins and the brain: from effects via receptors to drug targets.},
  author={Roger A H Adan and Willem Hendrik Gispen},
  journal={European journal of pharmacology},
  year={2000},
  volume={405 1-3},
  pages={13-24}
}
The lack of specific receptors (and antagonists) has hampered the research on the neural mechanism of action of adrenocorticotropic hormone (ACTH)- and melanocyte-stimulating hormone (MSH)-like peptides. Yet the original observations in the 1970s already pointed to cAMP as a possible mediator of ACTH/MSH effects in neurons. The cloning of melanocortin receptors since 1992, the identification of at least two subtypes (melanocortin MC(3) and MC(4) receptors) that are present in neural tissue and… CONTINUE READING

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