Melanocortins and body weight: a tale of two receptors

  title={Melanocortins and body weight: a tale of two receptors},
  author={David Cummings and Michael J. Schwartz},
  journal={Nature Genetics},
The phenotypes of mice lacking melanocortin-3 (Mcr3) and melanocortin-4 receptors (Mc4r) demonstrate that these isoforms reduce body weight through distinct and complementary mechanisms. Mc4r regulates food intake and possibly energy expenditure, whereas Mc3r influences feed efficiency and the partitioning of fuel stores into fat.