Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia.

@article{Delgado1998MelanocortinPI,
  title={Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia.},
  author={Rafael Toledano Delgado and Andrea Carlin and Lorena Airaghi and M T Demitri and Laura Meda and Daniela Galimberti and Pierluigi Baron and James M. Lipton and A. Fede Catania},
  journal={Journal of leukocyte biology},
  year={1998},
  volume={63 6},
  pages={740-5}
}
Inflammatory processes contribute to neurodegenerative disease, stroke, encephalitis, and other central nervous system (CNS) disorders. Activated microglia are a source of cytokines and other inflammatory agents within the CNS and it is therefore important to control glial function in order to preserve neural cells. Melanocortin peptides are pro-opiomelanocortin-derived amino acid sequences that include alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH… CONTINUE READING