Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism.

@article{Rodrigues2009Melanocortin5R,
  title={Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism.},
  author={Adriana R. Rodrigues and Duarte Pignatelli and Henrique Almeida and Alexandra Monteiro Gouveia},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={303 1-2},
  pages={74-81}
}
Melanocortin 5 receptor (MC5R) is a G protein coupled receptor (GPCR) with high affinity for alpha-melanocyte-stimulating hormone (alpha-MSH). To unravel some of the downstream cell-signaling pathways activated by this receptor, HEK293 cells were transiently and stably transfected with a vector encoding green fluorescent protein (GFP)-tagged MC5R. In these cells the receptor was correctly addressed to the cell surface and was functional, as shown by the MC5R-induced formation of intracellular… CONTINUE READING
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