Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

  title={Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat},
  author={Andrew A. Butler and Daniel L Marks and Wei Fan and Cynthia M. Kuhn and Mar{\'i}a Visitaci{\'o}n Bartolom{\'e} and Roger D Cone},
  journal={Nature Neuroscience},
In response to moderately increased dietary fat content, melanocortin-4 receptor-null mutant (MC4R−/−) mice exhibit hyperphagia and accelerated weight gain compared to wild-type mice. An increased feed efficiency (weight gain/kcal consumed) argues that mechanisms in addition to hyperphagia are instrumental in causing weight gain. We report two specific defects in coordinating energy expenditure with food intake in MC4R−/− mice. Wild-type mice respond to an increase in the fat content of the… CONTINUE READING


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