Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion.

@article{Liu2013Melanocortin4RI,
  title={Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion.},
  author={Jing Liu and Jacob C. Garza and Wei Li and Xin-Yun Lu},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 1},
  pages={105-20}
}
The central melanocortin system has been implicated in emotional stress-induced anxiety, anorexia and activation of the hypothalamo-pituitary-adrenal (HPA) axis. However, the underlying neural substrates have not been identified. The medial amygdala (MeA) is highly sensitive to emotional stress and expresses high levels of the melanocortin-4 receptor (MC4R). This study investigated the effects of activation and blockade of MC4R in the MeA on anxiety-like behaviour, food intake and… CONTINUE READING
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