Melanocortin-4 receptor–regulated energy homeostasis

  title={Melanocortin-4 receptor–regulated energy homeostasis},
  author={Michael J. Krashes and Bradford B. Lowell and Alastair S. Garfield},
  journal={Nature Neuroscience},
The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural… CONTINUE READING