Melanocortin 3 receptor (MC3R) gene variants in extremely obese women

  title={Melanocortin 3 receptor (MC3R) gene variants in extremely obese women},
  author={W Li and E Joo and E A Furlong and Margaret Galvin and Ken Abel and C M Bell and Robert A. Price},
  journal={International Journal of Obesity},
OBJECTIVE: Following several reports of linkage of obesity related phenotypes to human chromosome 20q we sought to determine whether variations of the melanocortin 3 receptor (MC3R) gene are associated with obesity.DESIGN: We screened the MC3R gene coding region and approximately 2 kb of 5′ and 3′ flanking sequences for DNA variants in unrelated extremely obese women and average weight controls using polymerase chain reaction (PCR) single strand conformation polymorphism (SSCP) analysis and DNA… CONTINUE READING


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