Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward

@inproceedings{Pandit2016Melanocortin3R,
  title={Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward},
  author={Rahul Pandit and Azar Omrani and Mieneke C. M. Luijendijk and Veronne A. J. de Vrind and Andrea J. van Rozen and Ralph J A Oude Ophuis and Keith M. Garner and Imre Kallo and Alexander Ghanem and Zsolt Liposits and Karl-Klaus Conzelmann and Louk J. M. J. Vanderschuren and Susanne E la Fleur and Roger A. H. Adan},
  booktitle={Neuropsychopharmacology},
  year={2016}
}
The central melanocortin (MC) system mediates its effects on food intake via MC3 (MC3R) and MC4 receptors (MC4R). Although the role of MC4R in meal size determination, satiation, food preference, and motivation is well established, the involvement of MC3R in the modulation of food intake has been less explored. Here, we investigated the role of MC3R on the incentive motivation for food, which is a crucial component of feeding behavior. Dopaminergic neurons within the ventral tegmental area (VTA… CONTINUE READING