Melanocortin 1 receptor variants: functional role and pigmentary associations.


The significance of human cutaneous pigmentation lies in its protective role against sun-induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by a low eumelanin to pheomelanin ratio, and have been associated with increased risk of skin cancer. Cutaneous pigmentation is a complex genetic trait, with more than 120 genes… (More)
DOI: 10.1111/j.1751-1097.2011.00970.x


3 Figures and Tables