Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways.

@article{Herraiz2009Melanocortin1R,
  title={Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways.},
  author={Cecilia Herraiz and Celia Jim{\'e}nez-Cervantes and Paola T Zanna and Jose Carlos Garcia-Borron},
  journal={FEBS letters},
  year={2009},
  volume={583 19},
  pages={3269-74}
}
Melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor expressed in melanocytes, is a major determinant of skin pigmentation, phototype and cancer risk. MC1R activates cAMP and mitogen-activated protein kinase ERK1/ERK2 signalling. When expressed in rat pheochromocytoma cell line cells, the R151C, R160W and D294H MC1R variants associated with melanoma and impaired cAMP signalling mediated ERK activation and ERK-dependent, agonist-induced neurite outgrowth comparable with wild-type. Dose… CONTINUE READING

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Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients

  • A. B. Perez Oliva, L. P. Fernendez, +7 authors G. Ribas
  • Hum. Mutat
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