Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands.


Binding of melanocortin peptide agonists to the melanocortin-1 receptor of melanocytes results in eumelanin production, whereas binding of the agouti signalling protein inverse agonist results in pheomelanin synthesis. Recently, a novel melanocortin-1 receptor ligand was reported. A β-defensin gene mutation was found to be responsible for black coat colour… (More)
DOI: 10.1111/j.1755-148X.2012.00990.x


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