Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy.

@article{Lpez2007Melanocortin1R,
  title={Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy.},
  author={Mercedes N L{\'o}pez and Cristi{\'a}n Pereda and Marcos Ramírez and Ariadna Mendoza-Naranjo and A. Serrano and Arturo Ferreira and Rodrigo Poblete and Alexis M. Kalergis and Rolf Kiessling and Flavio Salazar-Onfray},
  journal={Investigative ophthalmology \& visual science},
  year={2007},
  volume={48 3},
  pages={
          1219-27
        }
}
PURPOSE Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target for antitumor immunity. Because of the potential immunogenicity of MC1R, it is important to evaluate its expression on uveal melanomas. METHODS Two novel monoclonal antibodies (MP1.1C11 and MP1.1B7) were used to examine the expression of MC1R in uveal melanomas. Tissue samples… 
View on PubMed
iovs.arvojournals.org
32 Citations
Background Citations
9
Results Citations
1

32 Citations

Citation Type

Citation Type

Malignant melanoma and melanocortin 1 receptor
TLDR
The peculiarities of regulation and expression of MC1R, melanocytes, and melanoma cells are reviewed, along with the possible connection ofMC1R with signaling pathways regulating proliferation of tumor cells.
Melanocortin 1 Receptor–Targeted α-Particle Therapy for Metastatic Uveal Melanoma
TLDR
Significant potential is suggested for the clinical translation of 225Ac-DOTA-MC1RL as a novel therapy for metastatic uveal melanoma and significantly prolonged survival and decreased metastasis burden are demonstrated.
Immunobiology of Uveal Melanoma
Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients.
A Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte
TLDR
The results suggest that high-throughput sequencing technology provides a powerful tool to study mechanisms of tumogenesis in the molecular level and identify a large number of potentially interesting genes for biological investigation of uveal melanoma.
Molecular Imaging and Radionuclide Therapy of Melanoma Targeting the Melanocortin 1 Receptor
TLDR
These radiolabeled αMSH analogues showed promising results with high tumor uptake and rapid normal tissue activity clearance in the preclinical model of B 16F1 and B16F10 mouse melanomas, highlighting the potential of using radiolabed αHS analogues in clinical applications for molecular imaging and radionuclide therapy of melanoma.
Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update.
Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications
TLDR
Melanoma cannot be considered a “black box” for researchers anymore and current trends in the diagnosis and prognosis of melanoma are to individualize treatment based on molecular biomarkers.
In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma.
TLDR
The characterized MC1R-specific probe has excellent potential for in vivo detection of melanoma metastases and could aid in the translation of a targeted agent from lab to the clinic through an interdisciplinary approach.
Identification of the minimal melanocyte-specific promoter in the melanocortin receptor 1 gene
TLDR
It is shown that the 150 base pairs upstream the MC1R gene initiation codon are able to drive the melanocyte-specific gene transcription and provided experimental evidences suggesting that on such minimal melanocytes specific gene promoter can assemble tissue-specific complexes.
...
1
2
3
4
...

References

SHOWING 1-10 OF 49 REFERENCES
Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker
TLDR
Immunohistochemistry revealed a strong expression of melanocortin 1 receptor in all tested primary and metastatic melanomas, but also demonstrated low levels of expression in adrenal medulla, cerebellum, liver and keratinocytes, which may be of relevance for melanoma immunology and research on the pathogenicity of inflammatory conditions in the skin and neurologic tissues.
Immunophenotypic differences between uveal and cutaneous melanomas.
TLDR
There are differences between the 2 types of melanoma, and while cutaneous melanomas can be further subdivided into spindle and epithelioid types based on their immunophenotype, the uveal melanomas cannot.
Expression of MAGE, gp100 and tyrosinase genes in uveal melanoma cell lines
TLDR
Since at least two melanoma-associated antigens can be found in uveal melanoma cell lines, as well as the HLA class I molecules, these cell lines may be applicable as immunogens for specific immunotherapy against metastatic uveAL melanoma.
Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions
TLDR
S100A1 seems to be a possible candidate to differentiate conjunctival naevi from conjunctive melanoma, and S100B seems to differentiate between uveal melanoma and conjunctiver melanoma.
Immunohistochemical diagnosis of malignant melanoma of the conjunctiva and uvea: comparison of the novel antibody against melan-A with S100 protein and HMB-45
TLDR
Anti-melan-A was found to be a useful addition to antibody panels for ocular melanocytic lesions and has a higher sensitivity than HMB-45 in conjunctival and iris melanomas, but the sensitivity is similar to HMB in choroidal melanomas.
Immunological localisation of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells.
High frequency of allele‐specific down‐regulation of HLA class I expression in uveal melanoma cell lines
TLDR
A high frequency of allele‐specific and locus‐specific down‐regulation of HLA expression in uveal melanoma cell lines is found, which may explain why uveAL melanoma cells escape immune surveillance by cytotoxic T cells and complicate the development of immunotherapy in uvellent melanoma.
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.
TLDR
This work defines HLA-A2-restricted CTL epitopes from a recently cloned melanocortin 1 receptor (MC1R), which belongs to a new subfamily of the G-protein-coupled receptors expressed on melanomas and melanocytes and has implications in relation both to autoimmunity and immunotherapy of malignant melanomas.
Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA.
TLDR
It is demonstrated that all three MAbs recognize protein products encoded by a single cDNA, and co-distribution of the RNA species detected by the cDNA with the proteins recognized by the MAbs in tissue sections is demonstrated.
Recombinant antibodies against ganglioside expressed on tumor cells
TLDR
It is found that mAbs to GM2, GD2, and GD3 remain on the cell surface for ≥60 min after binding, while m Abs to other types of carbohydrate such as sialy Lea are quickly internalized.
...
1
2
3
4
5
...