Melanin protects Paracoccidioides brasiliensis from the effects of antimicrobial photodynamic inhibition and antifungal drugs.

@article{Baltazar2015MelaninPP,
  title={Melanin protects Paracoccidioides brasiliensis from the effects of antimicrobial photodynamic inhibition and antifungal drugs.},
  author={Ludmila de Matos Baltazar and Silvia Maria Cordeiro Werneck and Bet{\^a}nia Maria Soares and Marcus Vin{\'i}cius Lucas Ferreira and Danielle G Souza and M. Pinotti and Daniel de Assis Santos and Patr{\'i}cia Silva Cisalpino},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 7},
  pages={4003-11}
}
Paracoccidioidomycosis (PCM) is a public health concern in Latin America and South America that when not correctly treated can lead to patient death. In this study, the influence of melanin produced by Paracoccidioides spp. on the effects of treatment with antimicrobial photodynamic inhibition (aPI) and antifungal drugs was evaluated. aPI was performed using toluidine blue (TBO) as a photosensitizer and a 630-nm light-emitting diode (LED) light. The antifungals tested were itraconazole and… CONTINUE READING
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