Melanin pigmentation in mammalian skin and its hormonal regulation.

@article{Slominski2004MelaninPI,
  title={Melanin pigmentation in mammalian skin and its hormonal regulation.},
  author={Andrzej T. Slominski and Desmond J. Tobin and Shigeki Shibahara and Jacobo Wortsman},
  journal={Physiological reviews},
  year={2004},
  volume={84 4},
  pages={
          1155-228
        }
}
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways activated by receptor-dependent and -independent mechanisms, in hormonal, auto-, para-, or intracrine fashion. Because of the multidirectional nature and heterogeneous character of the melanogenesis modifying agents, its controlling factors are not… Expand
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References

SHOWING 1-10 OF 990 REFERENCES
Epidermal melanocytes : their regulation and role in skin pigmentation
TLDR
While there has been some debate concerning the pigmentary significance of the POMC peptides there now seems little doubt that these peptides are capable of stimulating human melanocytes. Expand
The melanosome: the perfect model for cellular responses to the environment.
  • V. Hearing
  • Biology, Medicine
  • Pigment cell research
  • 2000
TLDR
Studies targeted at elucidating the regulatory mechanisms involved and the functional changes that result demonstrate that the melanosome is the perfect model to study such biological response mechanisms. Expand
Molecular cascades in UV-induced melanogenesis: a central role for melanotropins?
TLDR
Available evidence supports a model in which melanotropins and their receptors play a central role in the process, and there are mechanisms in the skin for the orderly, regulated reception of UV signals that are then transduced to initiate the cascade. Expand
New regulators of melanin biosynthesis and the autodestruction of melanoma cells
TLDR
Three new factors which control melanin synthesis are described which appear to protect cells from the cytotoxic effects of melanin precursors, and indicates that regulation of the melanin biosynthetic pathway is more complex than previously supposed. Expand
The regulatory basis of melanogenic switching.
TLDR
The results support Ito's hypothesis, and suggest that melanogenic switching may be due to a jump between two stable production pattern states when the tyrosinase activity varies between two bifurcation levels, implying that small changes in the levels of external regulatory factors may cause an accentuated change in the proportion of the produced colour pigments. Expand
Cyclic AMP a key messenger in the regulation of skin pigmentation.
TLDR
It appears that melanogenic gene expression is controlled by a complex network of regulation involving other transcription factors such as Brn2, TBX2, PAX3 and SOX10, which would finally allow a fine tuning of melanocyte differentiation leading to melanin synthesis. Expand
Modification of melanogenesis in cultured human melanoma cells
TLDR
Since the hamster amelanotic melanoma line shows profound metabolic and cellular changes accompanying the induction of melanin synthesis by DMEM or L-tyrosine, it is tested whether the changes in pigmentation level in human melanoma cells are similarly accompanied by increased expression of tyrosinasc and MC1R genes. Expand
Regulation of Melanogenesis in Melanocytes
TLDR
The thesis pursued in this review explores the importance of the melanosome as the final common pathway of regulation of melanin biosynthesis. Expand
Enzymatic control of pigmentation in mammals
  • V. Hearing, K. Tsukamoto
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
TLDR
Future research should provide a greater understanding of the enzymatic interactions, processing, and tissue specificity that are important to pigmentation in mammals. Expand
Signaling pathways mediating melanogenesis.
TLDR
Recent progress in identifying signal transduction pathways that mediate melanogenesis is reviewed, which is the key physiologic defense against sun-induced injuries such as sunburn, photocarcinogenesis and photoaging. Expand
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2
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4
5
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