Melanin inhibits cytotoxic effects of doxorubicin and daunorubicin in MOLT 4 cells.

@article{Svensson2003MelaninIC,
  title={Melanin inhibits cytotoxic effects of doxorubicin and daunorubicin in MOLT 4 cells.},
  author={Samuel P. S. Svensson and Sofi Lindgren and Wendy Powell and Henrik Gr{\'e}en},
  journal={Pigment cell research},
  year={2003},
  volume={16 4},
  pages={351-4}
}
In the present study we have developed a simple method to elucidate the melanin binding ability of different chemotherapeutic agents. The anthracyclines, doxorubicin and daunorubicin, or the alkylating agent cisplatin were preincubated with melanin (Sepia). Melanin and free drug was then separated through centrifugation and the cytotoxic effects of corresponding drug were evaluated in a MTT (3-(4,5-dimetyltiazol-2-yl)-2,5-difenyl-tetrazoliumbromide) assay using MOLT-4 cells. Our results show… CONTINUE READING
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