Melanin counter act puromycin-induced inhibition of collagen and DNA biosynthesis in human skin fibroblasts.


Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of the fact that a number of drugs form with… (More)


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